JUPITER, Fla. (AP) — New York Mets ace Jacob DeGrom will miss significant time because of inflammation in his shoulder area, a huge blow to a team that heavily invested in making a deep run this season.

DeGrom won’t throw for up to four weeks and there is no timetable for his return, the Mets announced Friday.

New York Mets right-hander Jacob deGrom will miss Opening Day after imaging showed a stress reaction in his right scapula, sources tell ESPN. While the timetable for deGrom's return is unclear, he's expected to miss a significant amount of time to start 2022. Story soon at ESPN.

— Jeff Passan (@JeffPassan) April 1, 2022

The Mets said an MRI earlier in the day showed a stress reaction on his scapula that caused inflammation.

The two-time Cy Young Award winner had been set to start the season opener Thursday in Washington.

The Mets had boosted their rotation by signing three-time Cy Young winner Max Scherzer and trading for All-Star Chris Bassitt.

After getting off to a sensational start last year, deGrom didn’t pitch after July 7 because of a sprained elbow.